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Approximately 70 percent of human cancers show a similar metabolic phenotype, such as aerobic glycolysis characterized by increased glucose uptake and enhanced lactate production. In addition, human cancers are often characterized by dysregulated signal transduction due to imbalances in post-translational modifications (PTMs) of proteins. This suggests the interplay of signal transduction and metabolic pathway networks.
Dr. Taro Hitosugi, Ph.D., employs phosphoproteomics and metabolomiscs approaches to studying molecular mechanisms of this interplay. The ultimate goal of his research is to help patients through discoveries of metabolic enzymes or metabolites that are important for tumorigenesis with the hope of translating this work from bench to the bedside.
Dr. Hitosugi believes that the overall understanding of the interplay between signal transduction and cancer metabolism will help design novel drugs that specifically target the intersection between the dysregulated signaling and the changes in metabolisms that occur during transformation. In addition, this knowledge will help develop novel strategies for the combined use of kinase inhibitors and metabolic enzyme inhibitors. Also, his lab is pursuing discoveries in tumor suppressive metabolites in normal cells that can be used directly for the development of anti-cancer drugs with minimal side effects due to the chemical compounds in such metabolites already being present in normal cells.
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