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Nicholas M. Gregg, M.D., works to personalize neuromodulation approaches for epilepsy, to improve seizure control and to reduce epilepsy-related comorbidities. His research uses new techniques to characterize the connections between brain regions, and to track and modify brain network excitability over time. Ultimately, a detailed understanding of each patient's epilepsy condition will be combined with new models of brain connectivity and excitability. This new information will be used to optimize:
Dr. Gregg's work has a particular focus on the advancement of thalamic deep brain stimulation, responsive neurostimulation, and combined thalamic and cortical stimulation.
FDA-approved brain stimulation systems for epilepsy, including deep brain stimulation and responsive neurostimulation, effectively reduce the frequency of seizures for many people. However, seizure freedom is rare, and some individuals do not have an adequate response to therapy. By developing a deeper understanding of brain network connectivity and excitability, new approaches are possible to personalize the targeting and programming of neuromodulation devices for epilepsy.
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