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The research conducted by Ravindra (Ravi) V. Durvasula, M.D., focuses on developing new therapeutics and strategies to control transmission of infectious diseases. As a Howard Hughes Postdoctoral Fellow at Yale University, Dr. Durvasula developed a model system for expression of anti-trypanosomal molecules in the gut of the Chagas disease vector, Rhodnius prolixus. This work was funded by National Institutes of Health grants and has resulted in several additional lines of research into infectious diseases, including:
These projects involve strategies for design, expression and characterization of recombinant molecules that can be used for control of disease transmission.
Dr. Durvasula has pioneered new classes of intrinsically fluorescent antibodies and a new strategy for in vitro ribosomal display; he holds several patents in this area. Over the past few years, the Durvasula lab has expanded its work into the field of molecular design and drug discovery. Several programs with international collaborators are underway to design and develop new therapies for parasitic diseases such as malaria and leishmaniasis and illnesses caused by emerging viruses such as SARS-CoV-2, the Zika virus and the Ebola virus. His molecular design laboratory is also developing new antibody-based therapies for noninfectious conditions, such as chronic pain and post-stroke ischemia.
Dr. Durvasula's research aims to reduce the burden of parasitic and viral diseases on the global population by addressing both insect-mediated transmission and drug therapies for humans.
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