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The primary research focus for Alice Y. Chang, M.D., is polycystic ovary syndrome (PCOS), a condition of excess male-type hormones and insulin resistance. In particular, Dr. Chang studies what causes insulin resistance in women with PCOS in order to prevent the development of obesity, diabetes and other risk factors for heart disease. Current approaches include the use of metabolomics and response to drug therapy to identify disease-causing pathways in order to develop new therapies and individualize the treatment of PCOS.
Dr. Chang also conducts clinical trials in other conditions of excess male-type hormones such as congenital adrenal hyperplasia.
PCOS is the most common endocrine disorder in women of reproductive age. Dr. Chang's goal is to better treat the insulin resistance in PCOS that can significantly increase the risk of diabetes. Diabetes also significantly increases the risk of heart disease in all women with and without PCOS. With heart disease as the leading cause of death in women, understanding the mechanisms for insulin resistance and identifying new therapies to prevent the development of diabetes can significantly decrease the risk of heart disease in women with PCOS, and be helpful to all people with a high risk of diabetes.
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