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The research interests of Eva M. Carmona Porquera, M.D., Ph.D., center on investigations of lung defense, infection and fibrosis. Her research is aimed at better understanding lung defense as it relates to infection in immunocompromised hosts. Additionally, Dr. Carmona Porquera studies mechanisms of lung fibrosis in the idiopathic interstitial pneumonias.
B cells in the development of pulmonary fibrosis. Dr. Carmona Porquera and Tobias Peikert, M.D., are leading a study of the role of B cells in the development of lung fibrosis in a subset of patients with diffuse interstitial lung diseases. The main focus of this research is to determine the role of activated B-lymphocytes in driving fibroblast activation, which Dr. Carmona Porquera and colleagues believe plays a prominent role in the development of lung fibrosis.
The lab hypothesizes that the high risk of failure to the current medical therapies in these patients is the result of inaccurate selection or classification of these patients based on morphologic similarities rather than functional immunological studies. The proposed assays will help identify those patients, based on their functional immunological characteristics, and they hypothesize that B cell depleted therapies will likely to be successful when administered to the right patients.
Dr. Carmona Porquera's work with PCBG is very clinically relevant, as it could allow physicians to manipulate and increase immunity in patients with defective immune systems. Additionally, her work on a vaccine model for pneumocystis pneumonia will potentially help prevent this fungal infection.
Likewise, the B cell assays under development will predict patients at risk of developing lung fibrosis and also identify patients that will benefit from B cell depleted therapies, such as rituximab.
Finally, Dr. Carmona Porquera's analyses of LAM disease will contribute to the development of more-accurate diagnostic tools.
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