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Clinical Studies

Closed for Enrollment

  • Effect of Intermittent Hypoxia on Glucose Homeostasis: A Pilot Study Rochester, Minn.

    The purpose of this study is to see how changes in the amount of oxygen breathed can affect how the body responds to changes in blood sugar.
  • Effects of Hypoxia on Cognitive Performance: A Pilot Study with Human Physiological Model for Advanced Testing Rochester, Minn.

    The specific aim of this proposal is (1) to develop a human model of hypoxia in which cerebrovascular reactivity and cognitive function can be simultaneously measured and (2) develop pilot data in our laboratory on the relationship between cerebrovascular reactivity and cognitive function during three different hypoxic conditions with and without addition of inspired CO2 as a mechanism to maintain cerebral blood flow.
  • Experiential Pharmacogenomic Education for Providers: A Pilot Study Rochester, Minn.

    The aim of this study is to better understand providers’ attitudes, perceptions and knowledge of pharmacogenomics and to examine the impact of experiential education with providers.  
  • Infusing Social Learning Theory into Online Education Jacksonville, Fla., Rochester, Minn., Scottsdale/Phoenix, Ariz.

    Medical education and continuous professional development (CPD) are effective when it demonstrates translation of learning to clinical practice. The severe acute respiratory syndrome coronavirus 2 (COVID-19) pandemic has changed the landscape of CPD as in-person meetings and the associated social networking that occurs through these interactions has now largely disappeared. Limited data exists to guide the integration of social learning into online education; this study seeks to increase understanding of the impact of social learning on online education. The theory of planned behavior (TPB) will be used as a framework to evaluate impact.

    • AIM 1: Identify differences in knowledge acquisition, attitudes, values, beliefs, and intent to utilize pharmacogenomics (PGx) in clinical practice between two groups: one who has participated in an online PGx education program only and one who has participated in an online PGx education program and participated in small group discussion about the content led by a subject matter expert (PGx pharmacist). Small group discussion allows for learning from both experts and peers in a collective group that supports social interaction. It is hypothesized that those who participate in the small group discussion will score more positively in relation to knowledge, attitudes, values, and beliefs than those who participate in the online education only.
    •  AIM 2: Gain a deeper understanding of the practice impact of incorporating social learning theory constructs into online CPD education. This will be assessed by measuring the number of PGx tests and consults ordered after the CPD education. Further, a survey will measure self-reported use of PGx in making care decisions. It is hypothesized that those who participate in the small group discussion will be more likely to use PGx principles in the clinical environment and incorporate PGx information as a part of regular clinical practice. To achieve these aims, a randomized prospective study of physicians, nurse practitioners, and physician assistants who practice at throughout the Mayo Clinic enterprise will be conducted. Data from this study will help identify the impact of social learning theory on supporting implementation of PGx learning into practice and guide future endeavors.
  • Physiological Validation of Current Machine Learning Models for Hemodynamic Instability in Humans Rochester, Minn.

    The primary purpose of this study is to provide a subset of data using protocols of tolerance to lower-body negative pressure for validation of a commercially available wearable device that will be used in predicting hemorrhagic shock in persons suffering civilian and battlefield trauma.
  • Physiology of the Early Stage of Hemorrhage and Early Identification of Progression toward Hemodynamic Instability in Humans for Validation of Current Machine Learning Models Rochester, Minn.

    The purpose of this study is for collecting data on subjects undergoing lower body negative pressure (LBNP) to simulate progressive blood loss to look at different variables associated with blood loss.
  • Role of Aging and ATP: Compensatory Vasodilatory Response to Exercise During Hyperbaric Hyperoxia and Normobaric Hypoxia Rochester, Minn.

    The goal of this proposal is to investigate the “compensatory” vasodilator mechanisms responsible for changes in blood flow to maintain O2 delivery to contracting muscles during exercise with hypoxia (decreased O2 content) and hyperbaric hyperoxia (increased O2 content) in healthy younger individuals compared to healthy older individuals.
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