Ensayos clínicos

The purpose of this study is to better characterize the extent the pathways involved in AERD (leukotriene, prostaglandin, and thromboxane) impact coagulation pathways. 

The purpose of this study is to investigate the mechanism through which aspirin works for the prevention of nasal polyp recurrence in AERD patients, while comparing two aspirin doses: 325 mg once-daily or 650 mg twice daily dose of aspirin.

The objectives of this study are to determine longitudinal effects of aspirin desensitization on circulating immune cells in Aspirin Exacerbated Respiratory Disease (AERD) subjects, and to compare effects of sinus surgery on circulating immune cells in patients with AERD compared to patients with Chronic Rhinosinusitis with Nasal Polyps (CRSwNP). Immune cells in nasal polyp tissue removed at the time of endoscopic sinus surgery will also be compared to the profile of circulating immune cells before and after endoscopic sinus surgery and, for some subjects, after aspirin desensitization.

The purpose of this study is to learn more about aspirin exacerbated respiratory disease (AERD) by collecting blood samples from affected patients to study bleeding and clotting function.