-
A Biorepository for the Center for Multiple Sclerosis and Autoimmune Neurology
Scottsdale/Phoenix, AZ; Rochester, MN; Jacksonville, FL
The purpose of this study is to establish a repository consisting of clinical information, radiological data, serum, peripheral blood lymphocytes, plasma, cerebrospinal fluid (CSF), urine, stool, DNA and tissue specimens collected from patients who have central nervous system (CNS) inflammatory diseases.
-
Study to Validate Methods Assessment of Inflammatory Skin Disease
Rochester, MN
The purpose of this study is to assess the degree of signal alterations or attenuation in formalin-fixed vs. fresh skin biopsy specimens of inflammatory skin disease, using molecular methods .
-
Submandibular Gland Needle Core Biopsy and Skin Punch Biopsy as Tissue Biomarkers for the Diagnosis and Monitoring of Disease Progression of Parkinson’s Disease and REM Sleep Behavior Disorder
Scottsdale/Phoenix, AZ
Determine 1) the magnitude of SMG and skin a-syn density change over time, 2) the
improvement in adequate tissue acquisition doing bilateral SMG biopsies, 3) any laterality differences between
SMG gland a-syn density, 4) correlate a-syn density and changes in density between SMG and skin biopsies
Specific Aim 1. Determine, with bilateral submandibular gland (SMG) biopsies in 30 clinically
diagnosed subjects with Parkinson’s disease (PD) and 20 clinically probable REM sleep behavior
disorder (RBD) subjects whether bilateral biopsies improve the rate of acquisition of adequate
glandular tissue, whether alpha-synuclein (a-syn) SMG pathology ...
-
A Study to Evaluate Skin Angiosarcoma Imaging with Ultrasound
Rochester, MN
The purpose of this study is to to map out the extent of Skin Angiosarcoma disease using ultrasound. This will be compared to the MRI and or PET/CT and with clinical and photographic determination of disease extent confirmed with clinically requested punch biopsies. The patient will be scanned with a commercially avilable GE Logiq 10 machine and then with the 25-30 MHz linear microvessel transducer for microvessel imaging. These scans will be obtained pretreatment, after 2 cylces of neoadjuvant chemotherapy and after completion of neoadjuvant chemotherapy and radiation therapy prior to surgery.