Clinical Trials

The purpose of this study is to describe cerebral and retinal vasoreactivity in patients with cerebral small vessel disease (SVD) vs. healthy control, to describe temporal change of cerebral and retinal vasoreactivity, and to test the effectiveness of cilostazol in slowing the progression of white matter dementia (WMD).

The purpose of this study is to develop prognostic and diagnostic blood tests for symptomatic brain hemorrhage in patients diagnosed with cavernous angiomas, a critical clinical challenge in a disease affecting more than a million Americans. We further examine whether blood biomarkers can replace or enhance the accuracy of advanced imaging in association with lesional bleeding. The project tests a novel integrational approach of biomarker development in a mechanistically defined cerebrovascular disease, with a clinically relevant context of use.