Inclusion Criteria:

• Between 50 and 75 years of age, inclusive.
• Patients must have an Eastern Cooperative Oncology Group (ECOG) performance status 0-1.
• Patient must not have acute pancreatitis or a history of chronic pancreatitis.
• Patient must have received a computed tomography (CT) or magnetic resonance imaging (MRI) within 3 months of registration that revealed a newly identified ≥ 1 cm pancreatic cyst.
• Women of childbearing potential must not be known to be pregnant.
• Patient must not have a prior diagnosis of pancreatic cyst or pancreatic malignancy of any type.
• Patient must not have a history of pancreatic resection.
• Patient must not have other asymptomatic pancreatic cystic lesion with zero/low malignancy potential (pancreatic pseudocyst, classic serous cystic lesion) on index CT or MRI.
• Patient must not have a family history of pancreatic adenocarcinoma in 1 or more first degree relatives.
• Patient must not have pancreatic cyst morphology that would prompt immediate surgical consideration (enhancing mural nodule, solid component in cyst, pancreatic duct > 10 mm, cyst causing obstructive jaundice).
• Patient must not have a comorbid illness that precludes pancreatic cyst resection.
• Patient must not be participating in an already established surveillance program.

Exclusion Criteria:

• Under 50 or over 75 years of age.