Inclusion Criteria:

• Patient has a histology diagnosis of prostatic carcinoma/adenocarcinoma with a Gleason score.
• Patient has an elevated PSA, palpable prostate nodule, abnormal imaging finding or worrisome PSA velocity where prostate biopsy is planned.
• Male, age ≥ 18 years old.

Exclusion Criteria:

• Patients has a history of bladder cancer.
• Patient has had biopsy (within the last 6 weeks).
• Patient has had surgery to completely remove current target pathology.
• The current target pathology is a recurrence.
• Patient has had a transplant.
• Patient has received chemotherapy class drugs (e.g. Docetaxal, Methotrexate) or therapeutic radiation.
• Patient has had anti-androgen (Flutamide, Androcur, Casodex, Nilandron) or LHRH (Lupron, Zoladex) therapy.
• Patient has transurethral instrumentation (cystoscopy, placement of urinary catheter) within the past week.
• Patient has chronic indwelling urinary catheter.
• Patient has prior focal ablation (e.g. HIFU or cryoablation) of prostate cancer.
• Patient has had a urinary tract infection within 14 days of collection.
• Patient has ejaculated within 2 days of sample collection.