Inclusion Criteria:

• Age ≥ 18 but  ≤ 80 years old.
• ECOG performance status ≤ 2. 
• Cytologic or histologic proof of adenocarcinoma of the pancreas.
• Adequate renal, and bone marrow function:
  • Leukocytes ≥ 3,000/uL;
  • Absolute neutrophil count ≥ 1,500/uL;
  • Platelets ≥ 60,000/Ul;
  • Serum creatinine ≤ 1.5 mg/dL.
• Distant metastatic disease of peritoneum may be visualized on imaging:
  • Positive peritoneal cytology;
  • Limited carcinomatosis on diagnostic laparoscopy or laparotomy;
  • KRASD assay positive peritoneal washings/cytology.
• Completion of preoperative systemic chemotherapy with biochemical, metabolic, and/or radiographic response defined as a reduction in the baseline CA 19-9 by > 50% or radiographic response as defined by RECIST 1.1 or metabolic response on PET-MRI defined by PERCIST criteria.
• Peritoneal Carcinomatosis Index (PCI) ≤ 7 and surgeons deems high likelihood for a complete cytoreduction.

Exclusion Criteria:

• Distant metastatic disease not limited to peritoneum:
  • Solid organ metastases (liver, central nervous system, lung).
• Infections such as pneumonia or wound infections that would preclude protocol therapy.
• Women with a positive urine or serum pregnancy test are excluded from this study; women of childbearing potential (defined as those who have not undergone a hysterectomy or who have not been postmenopausal for at least 24 consecutive months) must agree to refrain from breast feeding and practice adequate contraception as specified in the informed consent. Adequate contraception consists of oral contraceptive, implantable contraceptives, injectable contraceptives, a double barrier method, or abstinence.
• Subjects deemed unable to comply with study and/or follow-up procedures.
• Subjects with a known hypersensitivity to protocol systemic chemotherapy that was life-threatening, required hospitalization or prolongation of existing hospitalization, or resulted in persistent or significant disability or incapacity.

Eligibility last updated 11/22/21. Questions regarding updates should be directed to the study team contact.