A Study to Identify Outcome Measures in Eosinophilic Gastrointestinal Disorders

Overview

Información sobre este estudio

The purpose of this observational study is to find the best measures to define how well a person with eosinophilic disorder is doing. People with eosinophilic esophagitis (EoE), eosinophilic gastritis (EG), and eosinophilic colitis (EC) normally undergo endoscopy and/or colonoscopy (scope down the throat or up the bottom) where tissue specimens are collected for microscopic analysis. Treatments are then decided based on how the tissue looks. We are aiming to compare different tissue components such as inflammatory cell types with clinical symptoms. We want to see if scores on standard questionnaires can give us an idea how well the person is doing.

Elegibilidad para la participación

Los requisitos de elegibilidad de los participantes incluyen la edad, el sexo, el tipo y el estadio de la enfermedad, y los problemas de salud o tratamientos previos. Las pautas difieren de un estudio a otro e identifican quiénes pueden o no pueden participar. No hay garantía de que cada persona elegible que desee participar en un ensayo se inscribirá. Comunícate con el equipo del estudio para analizar la elegibilidad del estudio y la posible participación.

Inclusion Criteria:

  • Males or females, 3 years of age and older.
  • Mucosal eosinophilia (≥ 15 eos/hpf for EoE, ≥ 30 eos/hpf for EG, ≥ 32 eos/hpf for EC).
  • Presence of symptoms is required for patients who are newly diagnosed but not required for patients who were previously diagnosed.
  • EC patients must have a history of one of the following at the time of colonoscopy:
    • anemia;
    • peripheral eosinophilia;
    • hemoccult positive stool;
    • Eosinophilic Gastrointestinal Disease (EGID);
    • allergic disease (allergic rhinitis, asthma, food allergy, eczema or other allergic features suggestive of atopic disease).

Exclusion Criteria:

  • History of intestinal surgery other than G tube placement.
  • Enrolled in a blinded investigational study.
  • Have esophageal stricture (< 3mm).
  • Have other identifiable causes for eosinophilia (except Inflammatory Bowel Disease):
    • infections;
    • Gastrointestinal (GI) cancer;
    • other GI inflammatory disease (e.g., Ulcerative Colitis or Crohn's Disease).

Sedes participantes de Mayo Clinic

Los estatus de los estudios cambian con frecuencia. Comunícate con el equipo del estudio para obtener la información más actualizada acerca de la posibilidad de participar.

Sede de Mayo Clinic Estatus Contacto

Scottsdale/Phoenix, Ariz.

Investigador principal de Mayo Clinic

Benjamin Wright, M.D.

Abierto para la inscripción

Contact information:

Benjamin Wright M.D.

(480) 301-4284

Wright.Benjamin@mayo.edu

More information

Publicaciones

Publications are currently not available