Inclusion Criteria:

- Males and females >= 15 years of age

- Newly diagnosed, histologic confirmation of pelvic chordoma, chondrosarcoma,
osteosarcoma, Ewing sarcoma with bone involvement, rhabdomyosarcoma (RMS) with bone
involvement or non-RMS soft tissue sarcoma with bone involvement

- No evidence of distant sarcoma metastases as determined by clinical examination and
any form of imaging

- Eastern Cooperative Oncology Group (ECOG) performance status (PS) =< 2

- Patients capable of childbearing must agree to use adequate contraception

- Ability to complete questionnaire(s) by themselves or with assistance

- Ability to provide written informed consent

- Chemotherapy per institutional guidelines is allowed

Exclusion Criteria:

- Patients receiving palliative treatment

- Recurrent disease

- Males and females < 15 years of age

- Previous radiation therapy to the site of the sarcoma or area surrounding it such that
it would be partially or completely encompassed by the radiation volume needed to
treat the current sarcoma. In other words, treatment on this study would require
re-irradiation of tissues

- Patients with distant sarcoma metastases

- Benign pelvic bone histologies

- Any of the following:

- Pregnant women

- Nursing women

- Men or women of childbearing potential who are unwilling to employ adequate contraception

Note: Other protocol defined Inclusion/Exclusion criteria may apply.

Eligibility last updated 7/27/22. Questions regarding updates should be directed to the study team contact.