Inclusion Criteria:

• Individuals between 18 and 90 years of age.

Cohort 1 - Individuals without history of Pancreatic Ductal Adenocarcinoma (PDAC) meeting any of the following criteria:

• 2+ relatives with PDAC on same side of family where 2 affected are first degree related to each other and at least 1 affected is first degree related to subject; age 50+ or ≤ 10 years younger than earliest PDAC in family at time of diagnosis.
• 2 affected first degree relatives with PDAC; age 50+ or 10 years younger than earliest PDAC in family.
• BRCA1, BRCA2, PALB2, ATM, MLH1, MSH2, MSH6, PMS2, EPCAM pathogenic or likely pathogenic variant AND 1 first or second degree relative with PDAC; age 50+ or 10 years younger than earliest PDAC in family.
• Familial Atypical Moles and Malignant Melanoma (FAMMM) with pathogenic or likely pathogenic CDKN2A variant; age 40+.
• Peutz-Jegher syndrome with STK11 pathogenic or likely pathogenic variant; age 35+.
• Hereditary pancreatitis with PRSS1 pathogenic or likely pathogenic variant and history of pancreatitis; age 40+.

Cohort 2 - Individuals without history of PDAC meeting any of the following criteria:

• ATM, BRCA1, BRCA2, or PALB2 pathogenic or likely pathogenic variant regardless of family history, age 50+.
• 2+ relatives with PDAC on the same side of family, any degree of relation, not meeting other criteria above; age 50+ or 10 years younger than earliest PDAC in family.
• 1 FDR with PDAC ≤ age 45; age up to 10 years younger than PDAC diagnosis in family member.

Cohort 3 - Individual meeting criteria for Cohorts 1 or 2 EXCEPT age (i.e., too young to qualify for Cohorts 1 or 2).

Cohort 4 - Individuals without history of PDAC presenting for evaluation who do not meet any criteria above after collection of full family history and/or germline testing.

Cohort 5 - Individuals who are not otherwise engaged in pancreas surveillance at a participating site may be invited to participate in the PRECEDE database and to donate a biosample (e.g., blood, saliva, and/or buccal swab) for discovery studies. This may include relatives of individuals in Cohorts 1-4 and individuals with personal history of PDAC. 

Exclusion Criteria:

• Individuals not meeting any single Inclusion Criteria.