Inclusion Criteria:

• Patients at least 18 years of age.
• Individuals diagnosed with any solid tumor cancer including, but not limited to, gastrointestinal, breast, gynecological, genitourinary, skin, CNS/brain, head/neck, musculoskeletal or cancer of unknown primary; and presenting to Mayo Clinic for clinical management/treatment; and patients receive genetic testing as described above.
• Self-identified as being from various ethnic populations including Hispanic/Latino, Native American/Alaskan, African American (including of African descent),Asian and other European populations.
• Blood collection is feasible (health, access and/or tolerability) for requested blood sample(s).
• Individuals have agreed to participate and signed the study informed consent form.

Exclusion Criteria: 

• Patients who have had prior germline genetic testing involving a 40+ gene panel within the last 24 months at Mayo Clinic and available for review by the research coordinator at time of consent.