A Study to Measure Markers of Immune Tolerance to Predict Women at Risk of Miscarriage or Failed Embryo Transfer

Overview

Información sobre este estudio

The purpose of this study is: 

Infertility Cohort - To determine if maternal blood concentrations of Gal-9, IL-4, and VEGF-A, -C, -D at the time of embryo transfer in patients undergoing in vitro fertilization are predictive of the cycle outcome: live birth or no live birth

Spontaneous Conception Cohort - To determine if maternal blood concentrations of Gal-9, IL-4, and VEGF-A, -C, -D early in the first trimester of gestation are predictive of miscarriage or live birth.

Elegibilidad para la participación

Los requisitos de elegibilidad de los participantes incluyen la edad, el sexo, el tipo y el estadio de la enfermedad, y los problemas de salud o tratamientos previos. Las pautas difieren de un estudio a otro e identifican quiénes pueden o no pueden participar. No hay garantía de que cada persona elegible que desee participar en un ensayo se inscribirá. Comunícate con el equipo del estudio para analizar la elegibilidad del estudio y la posible participación.

Inclusion Criteria - Infertility Cohort: 

  • Adult females undergoing a euploid frozen embryo transfer.
  • Women age 18 years of age or older.
  • Must be planning to have all blood work done at Mayo Clinic Rochester so we can receive the study samples.
  • Must be planning to deliver within the Mayo Clinic Health System so that we can review pregnancy outcomes.

Exclusion Criteria - Infertility Cohort: 

  • Non English speaking.
  • Less than 18 years of age.
  • Planning follow-up outside Mayo Clinic Rochester/MCHS.
  • Pregnancies with multiple fetuses.

Inclusion Criteria - Spontaneous Conception Cohort: 

  • Adult women presenting with positive pregnancy test to the Obstetrics Department.
  • Women age 18 years of age or older.
  • Confirmed intrauterine pregnancy (defined as gestational sac with yolk sac +/- fetal pole).
  • Patients need to be planning to deliver within the Mayo Clinic Health System so that we can review pregnancy outcomes.

Exclusion Criteria - Spontaneous Conception Cohort: 

  • Non English speaking.
  • Less than 18 years of age.
  • Planning follow-up outside Mayo Clinic Rochester/MCHS.
  • Patients desiring termination of pregnancy.
  • Known miscarriage at the time of recruitment.
  • Pregnancies with multiples.

 

Sedes participantes de Mayo Clinic

Los estatus de los estudios cambian con frecuencia. Comunícate con el equipo del estudio para obtener la información más actualizada acerca de la posibilidad de participar.

Sede de Mayo Clinic Estatus Contacto

Rochester, Minn.

Investigador principal de Mayo Clinic

Chandra Shenoy, M.D.

Abierto para la inscripción

Contact information:

Chelsie VanOort

(507)266-9642

VanOort.Chelsie@mayo.edu

More information

Publicaciones

Publications are currently not available