A Study to Evaluate a New Predictive Model for the Progression of Adolescent Idiopathic Scoliosis

Overview

Información sobre este estudio

The purpose of this study is to characterize the risk of scoliosis progression based on local three-dimensional vertebral and pelvic measurements present on initial evaluation. The proposed new study aims at refining and testing the external validity of this model in a larger cohort. The next step towards using the new model in the clinical setting is to redesign the model and to externally validate the model by measuring the agreement between the new method and the traditional Cobb angle at maturity in a larger multicenter study.  The ultimate goal of this research project will be to validate this new predictive model and finally transfer this new predictive tool in the hands of clinicians treating AIS.

 

Elegibilidad para la participación

Los requisitos de elegibilidad de los participantes incluyen la edad, el sexo, el tipo y el estadio de la enfermedad, y los problemas de salud o tratamientos previos. Las pautas difieren de un estudio a otro e identifican quiénes pueden o no pueden participar. No hay garantía de que cada persona elegible que desee participar en un ensayo se inscribirá. Comunícate con el equipo del estudio para analizar la elegibilidad del estudio y la posible participación.

Inclusion Criteria: 

  • Idiopathic Scoliosis (as diagnosed by the surgeon).
  • Patients above 10 years old at the time of recruitment.
  • Spina bifida occulta with no neurological signs and otherwise normal.
  • Curves ranging between 11º and 40º of Cobb angle measurement and - Risser 0 or 1, as measured on a standing postero-anterior digital radiograph of the spine. 
  • All single thoracic, thoraco-lumbar, lumbar, double major and triple major curves will be included in the study.

Exclusion Criteria:

  • Previous thoracic, pelvis or spine surgery as they may be co-factors in scoliosis initiation.
  • Congenital scoliosis, - MRI abnormalities (including > 4mm of Syrinx and/or Chiari malformation).
  • Syndromic scoliosis (associated with Marfan's or other genetic syndromes).
  • Neuromuscular scoliosis.
  • Developmental delay. 
  • Spinal asymmetry. 
  • Symptomatic spondylolisthesis. 
  • Leg length discrepancy longer than 1 cm. 
  • Unable or unwilling to firmly commit to returning for required follow-up visits.

Sedes participantes de Mayo Clinic

Los estatus de los estudios cambian con frecuencia. Comunícate con el equipo del estudio para obtener la información más actualizada acerca de la posibilidad de participar.

Sede de Mayo Clinic Estatus Contacto

Rochester, Minn.

Investigador principal de Mayo Clinic

Annalise Larson, M.D.

Abierto para la inscripción

Contact information:

Smitha Mathew M.B.B.S.

(507)538-3560

Mathew.Smitha@mayo.edu

More information

Publicaciones

Publications are currently not available