Inclusion Criteria:

• Diagnosis of dementia will be based on the DSM-IV criteria, and diagnosis of probable DLB will be based on the 4th Consortium Criteria and prodromal DLB (MCI-LB) based on the research criteria by McKeith et al.
• At least 18 years of age.
• Have a reliable informant who personally speaks with or sees that subject at least weekly.
• Subject is sufficiently fluent in English to complete all measures.
• Subject must be willing and able to consent to the protocol and undergo up to 6 visits. Baseline visit, 6 month visit and then yearly evaluations (year 1, 2, 3, and 4 from the baseline visit).
• Subject must be willing and able to undergo neuropsychological testing.
• Subject must have no contraindication to MRI imaging.

Exclusion Criteria:

• Presence of another neurologic disorder which could impact findings, such as multiple sclerosis, brain tumors, etc.
• Subject is unwilling to return for follow-up yearly, undergo neuropsychological testing and MR imaging.
• If undergoing Tau imaging cannot have QT Prolongation.
• Subject has no reliable informant.

Eligibility last updated 10/13/21. Questions regarding updates should be directed to the study team contact.