Inclusion Criteria:

• Patients undergoing surgery for polycystic kidney and liver disease or its complications or for a different renal or hepatic disease and wishing to participate in research studies of cystic liver and kidney disease.
• Patients with polycystic kidney and/or liver disease, undergoing percutaneous cyst aspiration and wishing to participate in research studies of cystic liver and kidney disease.
• Patients without polycystic kidney or liver disease undergoing nephrectomies or partial hepatectomies for other pathologies.
• Deceased fetuses with evidence of polycystic kidney and/or liver disease undergoing autopsy
• Deceased patients with polycystic kidney and/or liver disease undergoing autopsy.

Exclusion Criteria:

• Individuals who do not comprehend English (i.e., participants must be able to read and sign a consent form without the assistance of an interpreter)
• Individuals who are unable to sign consent (e.g., mentally challenged, those declared legally incompetent).
• Individuals regarded as belonging to a vulnerable population (e.g.prisoners).
• No age exclusion limit.
• Individuals with HIV or hepatitis infection.