Inclusion Criteria

• Male or female
• Age 18 to 100 years of age.
• Preoperative diagnosis of bacterial infection by culture which would include a preoperative aspiration and at least three intraoperative cultures
  • The preoperative aspiration would also be sent for a cell count with differential
  • All patients would have an ESR and CRP drawn in the preoperative phase
  • Patients with a negative preoperative aspiration, but an actively draining wound or draining sinus tract, would be considered as infected
  • Intraoperative histopathology would also be obtained in all cases of infected total knee replacement at the time of the resection.
• Intact extensor mechanism.
• Adequate soft tissue envelope (no requirement for soft tissue coverage such as a muscle flap or skin graft)
• Adequate bone stock for knee reconstruction
• Medical fitness for staged knee reconstruction

Exclusion Criteria

• Known atypical infection (mycobacterial or fungal)
• Extensor mechanism disruption
• Inadequate soft tissue envelope requiring muscle flap or skin grafting
• Inadequate bone stock (T3 or F3 by the AORI classification)
• Medical status precluding staged knee reconstruction
• Requirement for hinged knee reconstruction at the time of reimplantation
• Pregnant women
  • women of child bearing age will need a negative pregnancy test prior to enrollment to the study.